GsMTx4 

Selective blocker of mechanosensitive ion channels

壓力敏感性離子通道選擇性阻斷劑

GsMTx4 (GsMTx-4, M-theraphotoxin-Gr1a) has been isolated from the venom of the spider Grammostola rosea. This cationic hydrophobic polypeptide blocks selectively the gating of cation selective channels and mechanosensitive ion channels such as TRPC1 or TRPC6, without having any effect on whole-cell voltage-sensitive currents. This toxin acts by perturbing the interface between the channel and the lipid bilayer without necessarily being in physical contact with the channel. GsMTx4 also demonstrated to active TRPA1 channel at 1 M concentration and to inhibit Piezo1 currents.

GsMTx4 技術(shù)資料

氨基酸序列：

Gly-Cys2-Leu-Glu-Phe-Trp-Trp-Lys-Cys9-Asn-Pro-Asn-Asp-Asp-Lys-Cys16-Cys17-Arg-Pro-Lys-Leu-Lys-Cys23-Ser-Lys-Leu-Phe-Lys-Leu-Cys30-Asn-Phe-Ser-Phe-NH2 

二硫鍵：Cys2-Cys17, Cys9-Cys23 and Cys16-Cys30 

長度 (aa)：34

分子式：C185H273N49O45S6 

分子量：4095.2 Da

外觀：White lyophilized solid

可溶性：water and saline buffer 

CAS 號：not available 

來源： Synthetic 

純度：  97 %

產(chǎn)品信息

08GSM001-00050

GsMTx4

0.05mg

08GSM001-00100

GsMTx4

0.1mg

08GSM001-00500

GsMTx4

0.5mg